Principle #6 for Good Glycemic Control

Principle #1 Carbohydrate tolerance
Principle #2 Exercise
Principle #3 Cortisol
Principle #4 Food Quantity
Principle #5 Reproductive hormones

Principle #6 Inflammation

Inflammation is a common theme in virtually all disease processes. Many individuals can recognize the signs of more severe local inflammation like redness, swelling, heat, and pain, but many individuals have unrecognized chronic systemic inflammation.  Some symptoms of systemic inflammation include depression, brain fog, pain, fatigue, and malaise.  While systemic inflammation can give these symptoms, in some individuals it is without symptoms.  Chronic systemic inflammatory responses drive the development of blood sugar disruptions (insulin resistance).  Insulin resistance then promotes further inflammation creating a vicious cycle.  

    

Yours in health, Dr. Chris Caffery
URL:  www.functionalneuro.com
Facebook:  https://www.facebook.com/DrCaffery

Disclaimer:  The contents of this site are for educational purposes only.  Nothing here should be construed as medical advice.  Nothing here is a substitute for actual medical care.  Consult a qualified healthcare professional.

Leaky Gut in the Pathophysiology of Depression

“There is now evidence that major depression (MDD) is accompanied by an activation of the inflammatory response system (IRS) and that pro-inflammatory cytokines and lipopolysacharide (LPS) may induce depressive symptoms.”

“The results show that intestinal mucosal dysfunction characterized by an increased translocation of gram-negative bacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. It is suggested that the increased LPS translocation may mount an immune response and thus IRS activation in some patients with MDD and may induce specific sickness behaviour symptoms. It is suggested that patients with MDD should be checked for leaky gut by means of the IgM and IgA panel used in the present study and accordingly should be treated for leaky gut.”

Neuroendocrinol Lett 2008; 29(1):117–124

Yours in health, Dr. Chris Caffery
URL:  www.functionalneuro.com
Facebook:  https://www.facebook.com/DrCaffery

Disclaimer:  The contents of this site are for educational purposes only.  Nothing here should be construed as medical advice.  Nothing here is a substitute for actual medical care.  Consult a qualified healthcare professional.